Title

Systematic Review of Topical Amitriptyline for the Treatment of Neuropathic Pain

Document Type

Article

Publication Date

5-7-2015

Abstract

WHAT IS KNOWN AND OBJECTIVE:

Neuropathic pain is a common disorder for which patients seek treatment. The most common causes of neuropathic pain are diabetes, herpetic infection and chemotherapy-induced neuropathy. Oral administration of amitriptyline has traditionally been used for treating neuropathic pain; however, it has dose-related anticholinergic effects, which may limit its use in some individuals. Pharmacotherapeutic agents that are commonly used to treat neuropathic pain include antidepressants, anticonvulsants, opioids and opioid-like substances, and topical medications. The objective of this paper is to review the effectiveness of topical amitriptyline in patients with neuropathic pain.

Publication Title

Journal of Clinical Pharmacy and Therapeutics

DOI

10.1111/jcpt.12297