Medication errors account for 98,000 deaths every year according to Pham et al. (2012). This alarming statistic led to the following scholarly activity project question: What is the best evidence based practice for preventing nurse administered medication errors in the hospital setting? Although the literature review did not identify one specific preventive intervention as superior over others, findings suggested three methods as best practice. These three methods are the use of Computerized Provider Order Entry Systems, the five patient rights, and medication error prevention education. Methods included conducting a literature review, a policy and procedure review, and observation of medication administration error prevention techniques in the clinical setting. The policy & procedures and observations of medication administration techniques were consistent with findings in the literature. Implications for nursing practice, education, and research were provided.